On the way to begin his surgical residency at San Jose St. Bonaventure Hospital, Dr. Shaun Murphy witnesses an airport sign fall and shatter glass onto a young boy. With his unique ability to visualize the internal body and using improvised methods and tools, Shaun is able to stabilize the boy. In a hospital board meeting, Dr. Aaron Glassman, president of the hospital, tries to convince the board to hire Shaun, despite his autism. Throughout the episode, flashbacks were shown, revealing the picture of Shaun's childhood and his motivation for becoming a doctor.

Dr. Neil Melendez is doing rounds with Dr. Claire Browne and Dr. Jared Kalu. Melendez calls out Shaun for arriving late on his first full day. A middle aged woman is brought into the ER with abdominal pain. Shaun immediately diagnoses a malignant tumor. As punishment for lateness, Shaun is assigned 'scut work', where his attention to detail gets him in trouble. After rechecking a discharged young girl's test results, Shaun races to her home, annoying her parents over the late hour, but eventually saving the girl's life. Additionally, Shaun's idea saves the cancer patient's life, but Jared presents the idea as his own and takes all of the credit. Afterwards, Andrews stands up for Shaun and forces Melendez to put Shaun back on the team.

Shaun and Claire fly to San Francisco Municipal Hospital to get a liver for a transplant patient. After learning the helicopter can't take off due to bad weather, they resort to a police escort. During this, Claire learns to communicate with Shaun, bonding with him in the process. Meanwhile, at the Hospital, Chuck, the recipient of the liver, is discovered to have alcohol in his system, a development that could void his transplant eligibility. Chuck later confesses he had one drink at his daughter's graduation. In order to protect its reputation and ability to supply transplants to future patients, the hospital denies Chuck the liver. Shaun and Claire arrive back, having kept the liver viable, only to learn that it is to be taken to a patient at another hospital. Elsewhere, Shaun meets Lea, a female neighbor at his apartment complex.

Barb Allen, 22 weeks pregnant, and her husband arrive at St. Bonaventure, hoping the doctors can save their baby. A large non-cancerous tumor is growing on the fetus and must be removed in order to save his life. Despite the serious risks both to her and the baby, Barb insists on surgery. Meanwhile, Shaun and Claire are assigned a patient, Olivia, who has a boil in her genital area. However, when doctors attempt to drain it, a fibroid tumor is found to be wrapped around a nerve. The surgery to remove it will cut off all feeling in Olivia's genitals. Shaun comes up with a solution that allows her to keep feeling in her genital area.

Shaun notices a young boy, Evan, who has an uncanny resemblance to his deceased brother Steve. Evan was brought to the hospital by his parents for a possible fracture to his arm. However, we discover that he is actually suffering from terminal bone cancer, a fact his parents have kept hidden from him. Shaun attempts to find another diagnosis and save Evan, earning him the scorn of his colleagues. Evan's terminal cancer diagnosis is ultimately confirmed with the revelation that it has metastasized into his chest cavity. However, Evan reveals that he has secretly known the truth for a long time and accepts his situation, but is thankful for Shaun's attempts to help him. Meanwhile, the other members of the team try to diagnose an older man, brought in by his estranged son, with a severe allergy condition causing him to convulse violently. Claire and Jared determine that the man is suffering from a cystic form of tapeworms located in his skull. A successful surgery is performed by Dr. Glassman.

Shaun and the rest of the residents are working the graveyard shift when numerous casualties from a wedding bus crash come in. Among the victims is a woman with severe, visible burns, on whom Jared tries an experimental procedure, and a young man with a severely damaged leg. Tensions arise between the patient's parents and fiancée over the best choice for treatment; his parents want to amputate the leg, his fiancée is in favor of an experimental bone-replacement procedure. Due to Jessica filing an injunction, a judge is left to make the decision and after hearing all sides, goes with the bone-replacement. Melendez and Shaun are able to save the man's leg and though he will have a long recovery, he is expected to be fine. After treating a patient, Claire realizes that a woman has been left behind at the crash site. Claire and Glassman successfully treat the woman for a brain bleed, but discover afterwards that she is mysteriously brain dead and she doesn't survive. Glassman later realizes that Claire had improperly intubated the patient at the crash site, causing hypoxia and leading to her brain death.

Shaun encounters Liam, an autistic patient, when he is admitted to the hospital. Having to face prejudice from the young man's parents, Melendez defends Shaun for the first time and acknowledges his exceptional abilities. After Liam voices his support for Shaun doing the surgery, his parents allow it. Melendez allows Shaun to take a more active role in the surgery and Shaun saves Liam's life during a dangerous part of it. In the aftermath, Shaun helps Liam's parents to see how their overbearing and overprotective nature towards their son lead to him getting sick in the first place. As a result, Liam's parents start asking Liam for his opinion on things rather than unilaterally making decisions for him. On Glassman's directive, Claire continues with therapy sessions in order to curb her guilt over inadvertently causing the death of a patient. Jared treats a 73-year-old man with severe chest pains who needs urgent medical attention and a pacemaker, but the patient states his desire is to die. Ultimately, Jared chooses to honor the man's wishes, but stays with him as he dies. Afterwards, Jared and Claire comfort each other over the loss of their respective patients.

While Shaun is shopping at a grocery mart for apples, a robbery takes place. With Shaun's communication limitations, he puts the lives of two customers on a first date at risk, leading to a young woman getting shot. Shaun's neighbor Lea hugs him after he admits that he made a mistake and got someone hurt; though he doesn't hug back, he is shown to relax in her embrace. During surgery, Lim questions Claire's ability to not let her emotions get the better of her because of a racist patient, the shooter in the robbery. This leads to an argument between the two, with Lim ordering Claire to leave the operating room. Claire puts her emotions in check to save the life of the racist patient, then makes amends with Lim.

The team takes on the case of a young boy from the Congo who has severe congenital heart anomalies. Working together, Shaun and Melendez devise a procedure to treat the boy; despite difficulties it is ultimately successful. Shaun's latest encounter with his neighbor Lea has him confused. He takes flirting lessons from Claire, noting and charting what he sees in regards to the "flirting trifecta." Meanwhile, Claire, along with Dr. Carly Lever, searches for a misplaced tissue sample from a woman with possible throat cancer. At the last minute, Claire finds the sample in a mislabeled container and the patient turns out to be cancer free.

Shaun reluctantly agrees to Dr. Glassman's repeated suggestions to meet with a therapist, but ultimately changes his mind after a new patient, Bobby Ato, convinces Shaun to stop letting people tell him what to do. Claire runs into an uncomfortable situation when Dr. Matt Coyle makes unwanted sexual advances toward her during a patient consultation. Jared finds out and physically threatens him. As a result, Jared is fired. After a tense dinner with her father and Dr. Melendez, Jessica states that she doesn't want to have children.

Shaun and Lea embark on an impromptu road trip. Shaun experiences many firsts: driving, drinking Tequila, singing karaoke, and even his first kiss with Lea. However, during the trip, Lea states her intention to move to Hershey, Pennsylvania, which devastates Shaun. Melendez and Andrews operate on conjoined twins, one of whom needs a kidney. Complications develop and the operation to separate them, planned for six months after the kidney surgery, must be done immediately. The operation goes well until it's discovered the twins have not awakened from the surgery. Melendez decides it's more important to be with Jessica and that he can be a "father" in other ways.

Shaun returns to the hospital after his trip and gives Dr. Glassman his two weeks' notice, intending on moving to Hershey to be with Lea. The twins suffer complications from their surgery; Katie is not getting enough blood flow to the brain and Jenny's heart is failing. Despite the doctors' best efforts to save both twins, Jenny dies on the operating table. After allegations of racism by Kalu's lawyer, Jessica is forced to look into previous misconduct incidents at the hospital in which white doctors were only warned instead of fired; as a result, Jared is reinstated. When he returns to work, he is met with the cold shoulder by Andrews, who tells him he sets civil rights back when he looks for racism where there is none. Jessica tells Melendez that she wants to break up because she feels like she is standing in his way of being a father.

While treating a Muslim patient, Shaun senses she is lying and makes controversial claims about how she sustained her injuries. Melendez punctures the bronchus of the patient during surgery and is put under investigation after Shaun questions if his personal life is affecting his work. While Claire assists in Dr. Lim's surgery on a stroke patient who had an aneurysm, she learns that Coyle got a new job and a raise. They inform the patient's wife that he needs surgery or he will die, but she refuses to consent until Claire explains the reality of the situation. Shaun asks Glassman to be friends, but Glassman decides to give him his own space and not be his friend, which upsets Shaun.

The four residents, including the new Dr. Morgan Reznick, are paired off in competition; Reznick and Browne with Melendez, Murphy and Kalu with Lim. Murphy and Kalu are faced with a gender dysphoric patient, Quinn, which leads to friction when Murphy claims that sex and gender are one and the same. Murphy and Kalu determine that Quinn has testicular cancer along with fragile bones caused by puberty blockers. Browne and Reznick tend to a male patient that has contracted a superbug resistant to all medication as a result of taking leftover prescription medication for the wrong purposes. Drs. Andrews and Barnes see a fertility specialist, as they are having trouble conceiving.

A female teen goes through a risky surgery to implant a sternum so she can live a normal life without being confined to her house. A young boy initially rejects the idea of having a convicted killer's liver transplanted in him but, without it, he has a day to live. A former 15 year veteran cop-turned-doctor, Alex Park, is skeptical of the convict, Boris', motives. Allegra talks to Dr. Andrews about a young wealthy donor, Aidan Coulter, but Andrews says being involved with him might give people the wrong idea that she used sex to solicit donations. At a fundraiser, Jared tells Claire he loved her and thought maybe she would one day love him, but came to the realization that wasn't true, leaving the status of their relationship unknown.

Shaun, Claire, and Alex assist Melendez with one of his first patients, a man named Hunter who was paralyzed in a motorcycle accident ten years prior. Jared, Morgan, and Andrews attend to a patient with an infection caused by plastic surgery. Claire's estranged mother shows up at the hospital saying she wants to reconnect but, in reality, she takes advantage of Claire once again. Andrews sees an infertility specialist that tells him there is a surgery that could help him with his sperm count, but with a risk of impotence. Alex does a background check on Kenny which sheds light on his criminal past, leading him to suggest Shaun is being used by him.

Shaun and Alex treat teenaged Gretchen's Möbius syndrome, enabling her to smile; Andrews persuades an insurance executive to cover the surgery. After Gretchen fails to wake up, it is believed that she has become brain dead, but Park realizes that a rare condition is causing her to remain under anesthesia and she recovers. Morgan and Claire's patient, "Lucy Callard," is actually an identity thief who let her insurance lapse to pay her son's college tuition and failed to fill her post-operative antibiotic prescription due to fear of discovery, resulting in a post-op infection. Morgan convinces the real Lucy Callard, a painkiller addict, to enter rehab; Claire gains the trust of the imposter, Beatrice, who dies after her infection turns into sepsis that fails to respond to treatment. Jared romantically pursues his burn-victim patient, Celez, after she completes her treatment; he is also offered a job in Denver. Kenny takes advantage of Shaun. Shaun urges Glassman to date hospital barista Debbie; they hit it off over their interest in classic cars, but Glassman suddenly experiences aphasia at the end of their dinner date.

Glassman tells Shaun about his inoperable glioma and that he has 18 months left to live. He accepts his death, but agrees to additional imaging for Shaun's sake; this yields a worse prognosis of four months to live. Glassman takes Shaun to a park his late daughter loved so they can enjoy the time Glassman has left. Shaun determines how a minimally invasive biopsy could be performed, which later proves that Glassman's cancer is operable and, though it'd be a long road to recovery, he'll most likely survive. A patient, Caden, suffers complications after treatment for a fraternity hazing injury. Jared and Alex question Caden's friend, but Jared is put off by Alex's distrustful nature. Shaun determines that he erred in clamping Caden's artery, offering to take full responsibility for it. He proposes a risky procedure as a fix and Melendez decides they should perform it together. Caden survives and Melendez invites the team out for drinks, which Morgan finds perverse; Melendez hopes a doctor supports her when she inevitably kills a patient. Shaun decides to admit his mistake to Andrews, though Glassman's position would be at stake; Glassman leaves the decision up to Shaun and accompanies him to meet with Andrews.

In performance reviews, Andrews, now president of the hospital, tells Shaun to learn to communicate, Claire to be more assertive, and Morgan to improve her teamwork. Jared, working his last day before moving to Denver, skips his. Jared and Shaun run a mobile clinic and meet Harry, a mentally unstable homeless man. When Shaun takes Jared's advice to spend time with Glassman, who is beginning his cancer treatment with Dr. Blaize (his last hire before being replaced), it leads Shaun to diagnose Harry with a brain tumor. Shaun has a communication breakthrough in persuading Harry (whose real name is Edward) to receive treatment, which is successful and enables him to reunite with his family. Shaun commits to standing by Glassman through his treatment. Andrews, following Allegra's advice that Glassman was manipulative, persuades Melendez to perform a risky heart surgery that could raise the hospital's public profile. Claire resolves a complication, and Morgan encourages her to take credit. The procedure is a success, and Claire acknowledges her innovation. Claire has a change of heart and asks Jared to stay, but he tells her they will both be happy apart before leaving for Denver. Lea unexpectedly greets Shaun outside his apartment.

Shaun and Claire assist Dr. Melendez in treating Paul, a hospital janitor Shaun has diagnosed with pancreatic cancer and one year to live. Paul's wife and adult children encourage him to have risky surgery; Paul agrees, telling Shaun he wants to please his family, and advising Shaun to lie when the truth is unhelpful. Paul dies from a complication and his family begins to squabble over having coerced Paul; Shaun lies, telling them that Paul wanted the surgery. Dr. Lim treats Mara, a sixteen-year-old American girl with scarring from female genital mutilation, risking liability in willfully ignoring Mara's fake ID. Mara experiences extreme pain, revealing live tissue; with her parents and Child Protective Services involved, Mara declines reconstruction in favor of clitoridectomy, but Lim performs the reconstruction without consent; Mara is apparently pleased with the result and Lim's discretion. Dr. Glassman delays picking a neurosurgeon, fearing he could survive but suffer permanent disability; at Dr. Blaize's insistence, Glassman undergoes surgery. Shaun avoids his houseguest Lea for days, telling Claire he doesn't understand his own feelings. He tells Lea she hurt him, and he wants her to leave before she hurts him again.

On 36-hour shifts, Shaun and Morgan manage the emergency room in Dr. Lim's absence while Claire and Alex assist Dr. Melendez. Melendez performs surgery to treat a woman's endometriosis and restore her fertility. Her condition is more severe than realized, and the planned hour-long surgery stretches to over 22 hours; tensions rise among Melendez, Claire, and Nurse Flores. When a risky procedure is the only way to avoid a hysterectomy, the patient's husband refuses to make a decision; he cedes the responsibility to Claire, who overrides Melendez's decision; they perform the hysterectomy. Called before Dr. Andrews over their bickering, Melendez, Claire, and Flores have only praise for each other. Shaun and Morgan safely extract a light bulb from a child's mouth and treat a young man whose priapism reveals an abscess. In traffic court, Lim fails to get a ticket dismissed and is jailed for contempt of court; she is later called away to operate on the abscess, interrupting a tryst with the prosecutor. Shaun apologizes to Lea; but she criticizes him for hurting her and failing to reciprocate her friendship. Glassman wakes from his successful surgery, and has a vision of his dead daughter, Maddie.

Mac, a boy with fragile X syndrome, injures himself and his mother, Nicole. Alex and Shaun believe Nicole should send Mac to a group home; at Melendez's recommendation, Nicole agrees. Shaun recalls living with a tough-loving foster mother who became terminally ill. Dr. Lim, Claire, and Morgan treat injured 18-year-old female free solo climber Kitty; her parents, disapproving a risky surgery that could preserve Kitty's athleticism, obtain a declaration of medical incompetence and authorize a safer procedure that may leave her disabled. Kitty disowns her parents; Claire tries to reconcile them, but nobody changes their decision. Claire and Melendez discuss how their baggage influences their advice. Claire struggled with her irresponsible mother, and Melendez's developmentally challenged sister Gabi lives in a care home. Glassman's daughter Maddie, who became a heavy marijuana user as a teen, died when Glassman locked her out at night as punishment; Glassman has an emotional confrontation with the hallucination of Maddie, and they confirm their mutual love. Shaun struggles to make amends with Lea, succeeding only when he asks what happened in Hershey. Lea is stunned to learn Shaun has rented a two-bedroom apartment for them to share.

Dr. Brown administers a Precordial thump. Dr. Lim treats Wade who, due to Crohn's disease and a fistula, must have his gastric bypass reversed. Wade keeps his past obesity secret from his husband, Spencer. Divorcees Alex and Lim disagree over marital honesty; Alex considers it more important. Wade tells Spencer he kept the secret because Spencer mocked their overweight friends. Spencer admits to Alex his unease at knowing Wade could regain the weight. Dr. Melendez treats Louisa, an anorexic mother suffering mitral regurgitation; her mental illness prevents the weight gain she needs before surgery. Melendez wants to operate despite the risks, rejecting Claire's suggestion of deep brain stimulation; she presents the option to Louisa, who requests it. Melendez is the review board's deciding vote for DBS, but he removes Claire from his team for not accepting his decision while telling her it was Andrews who voted against her. After DBS, Louisa wants to eat, but feels less bonded to her son, a risk she understood and accepted. Glassman is too self-conscious to attempt walking until Shaun brings Debbie to convince him, making Shaun doubt his importance to Glassman. Shaun and Lea talk through her fear that living together will damage their platonic friendship; she ultimately agrees to move into the new apartment with him.

Now working with Dr. Lim, Claire treats a teenage girl, Riley, for severe respiratory problems. Riley's parents believe she is making herself sick over their divorce, but Claire suspects a tumor. When Riley's condition worsens, Claire convinces her parents to allow exploratory surgery; Park initially doubts Claire, but ultimately helps her. They discover and remove an inhaled Lego from Riley's lung; her years-long illness was an immune response to the foreign object. Shaun and Morgan disagree over treating Jas, a violinist: Shaun believes she has flesh-eating bacteria which Morgan, a former archer, is reluctant to test for, since if wrong, it could ruin Jas's career. Morgan's hesitation leads to them being forced to amputate Jas's arm when her condition worsens. Melendez advises Morgan, devastated by her mistake, that she and Shaun have different strengths, as did he and Dr. Lim during their residency. Debbie helps Glassman recover at home, but he asks her to leave after he is injured when they attempt intimacy. Shaun and Lea struggle as new roommates. Glassman tells Lea, if she can't be Shaun's roommate she should move out immediately; to Shaun's delight, Lea commits to resolving their conflicts and sharing the apartment.

Claire's college roommate Kayla has terminal ovarian cancer; Claire persuades Dr. Melendez to perform a pain-relief procedure, and a life-extending treatment option emerges. At Kayla's insistence, Claire works on Melendez's team with Alex. Kayla asks her husband Dash and Claire to date if she dies, and sends them to dinner together. Kayla wants Dash to be taken care of and Claire to open her heart. Claire accuses Kayla of being controlling; during the second procedure, Claire resolves a complication. Claire and Kayla make peace; Claire urges Kayla to focus on herself. Claire and Melendez commend each other, but agree to not work directly together. Dr. Lim, Shaun, and Morgan treat Santiago, who needs a kidney transplant. His perfect-match brother, Armando, will donate only if Santiago sells the family business, granting Armando economic freedom. Shaun leads the brothers to discuss their father's legacy. Armando donates the kidney condition-free, improving their relationship. Dr. Glassman suffers a memory lapse. Shaun and Lea's new fish Hubert dies; Lea is reminded of the failure of her professional and personal relationship with her brother in Hershey. Shaun comforts Lea by proving that Hubert died of a parasite unrelated to her caretaking; they get a new fish.

Morgan and Park treat Finn, whose parents don't believe in vaccines. Finn has diastematomyelia, a congenitally split spinal cord. During Finn's treatment, his mother Bethany allows Park to vaccinate him. Finn is treated successfully, but Bethany acted without her husband's knowledge, threatening their marriage. In a failed effort to reconcile them, Park emotionally tells the husband a story (which Park later claims is untrue) of a family that fractured when a couple failed to address the wife's dishonesty. Shaun and Claire treat Todd and Dawn, a couple whose car crashed. Dawn's miscarried ectopic pregnancy reveals her infidelity, as Todd had a vasectomy. Claire determines a tumor has eliminated Dawn's inhibitions; it is removed, but Todd only forgives Dawn after Claire points out that, despite acting on every impulse, Dawn never left him, showing she truly loves Todd. With Claire looking for other jobs, Dr. Andrews tells Melendez Claire's departure would endanger Melendez's promotion. So Melendez can avoid choosing between disobeying orders and looking weak, Claire extends an openly insincere apology; he restores her to his team. At Dr. Glassman's request, Shaun privately tests his memory. Glassman cannot remember Shaun's brother's name, confirming the lapses.

Claire and Morgan treat George, a pedophile who has never acted upon his urges. The hormones that suppress his urges have caused a stroke; he must discontinue them. He mutilates his scrotum and asks the doctors to castrate him. Claire and Morgan eventually agree, but they and Dr. Melendez must instead repair his testicles to prevent unsurvivably low testosterone. George commits suicide; Morgan suggests the outcome is satisfactory. Alex and Shaun treat Billy, a severely beaten juvenile offender. Alex wants to repair an old dent in Billy's forehead, caused by his father's abuse, which led to the beatings; Dr. Lim initially opposes the unnecessary cosmetic procedure, but accepts Shaun's simplified approach. Shaun rejects Billy's praise, because Billy suffered a dangerous complication. Alex reveals Billy had been planning suicide; Shaun saved Billy's life, and exhibited empathy, an area Shaun considers a deficiency. Allegra demands Andrews choose a new Chief of Surgery. After initially considering between Melendez and Lim, Andrews ultimately retains the title himself; Melendez and Lim later agree to be allies instead of competitors. Shaun takes away Glassman's driver's license. Lea teaches Shaun to drive, using flawed but effective surgical metaphors, so Shaun can transport Glassman.

After sleeping together, Drs. Lim and Melendez agree not to do so again despite both having enjoyed it. The ER and its waiting room are quarantined after two patients, travelers returning from Malaysia, die of a viral respiratory disease. Those quarantined include Shaun, Morgan, Lim, and Alex's estranged son Kellan. Morgan treats Tyler, an infected EMT with whom she shares a developing romance; Tyler dies despite Morgan's impassioned efforts. Lim gets infected and isolates herself. Mall Santa Pete's bowel obstruction requires surgery without benefit of standard equipment; Lim collapses while talking Morgan through a vital part of the surgery. Shaun also collapses, overwhelmed by sensory overload. Kellan suffers an asthma attack, causing panic when patients think he is infected with the virus. Elsewhere in the hospital, Melendez and Claire struggle to keep leukemia patient Chris alive. Chris's marrow donor, his estranged father Bob, is trapped in quarantine; Chris flatlines and Melendez & Claire struggle to revive him despite Chris' DNR. With Shaun unavailable, Lea takes Dr. Glassman for an MRI to check on the status of his cancer; his tumor is confirmed to have returned.

Morgan revives Shaun by getting him to focus on Santa Pete's condition; with Shaun's help, Morgan successfully completes the surgery. Melendez and Claire revive their patient and devise a way to perform the bone marrow transplant with Andrews' help. Park breaks quarantine to treat Kellan's asthma attack and extracts Bob's bone marrow with the help of retired veterinarian Esther; the transplant is a success but Bob dies of complications. Esther later conveys Bob's final regrets to his son. Morgan treats Doctor Lim using extracorporeal membrane oxygenation which proves successful and she survives. Morgan realizes that Tyler's ripped mask led to him getting sick and the virus is not airborne; no one else contracts the virus and quarantine is later lifted. Pregnant Viola suffers complications, forcing Shaun to perform a C-section. With the help of Kellan, Shaun saves both mother and child. Inspired by Bob's regrets, Park reconciles with Kellan and allows his ex-wife to comfort him when she arrives. Glassman discovers that his cancer has not returned but that he has meningitis, explaining his memory loss. Glassman and Lea argue over telling Shaun and their respective roles in his life; Glassman chooses to tell Shaun the truth in the end and they share a rare hug.

In the aftermath of the quarantine, the governor orders a review of the hospital; the investigator expresses concern about Andrews maintaining his dual role and recommends Shaun, Lim, and Melendez to the medical board for license suspension over their actions. With the ER closed for cleanup, Park spends the day with his ex-wife Mia and son Kellan, Morgan and Claire spend the day helping Claire's mother pack up her apartment, and Shaun and Glassman spend the day with Lea. Park and Mia decide to work on repairing their relationship. Morgan and Claire confront Claire's mother's boyfriend, whom she claims beat her, only to learn that he never abused her; she is panicked because he proposed to her. Claire convinces her mother to work at the romantic relationship. Morgan admits she is sad about Tyler's death. Claire is impressed that Morgan, who once had a stalker, confidently carries a gun and doesn't back down. Glassman decides to speed up his treatment after a fun day while Shaun learns that Lea has a boyfriend, Jake. Lim and Melendez's night together complicates things for them; they ultimately admit to mutual feelings; due to the legal proceedings, they decide to pursue a secret relationship.

Claire, Park, and Melendez treat an elderly patient, Sunny, with an estranged biological daughter Grace and a surrogate daughter Teresa. Sunny's mechanical heart is malfunctioning; with her condition deteriorating, the doctors are forced to operate rather than send Sunny to her doctor in China; the surgery is a success. Afterwards, with support from Park and Teresa, Sunny and Grace begin mending their relationship. At the same time, Lim, Morgan and Shaun treat an autistic patient, Lana, whose brain aneurysm requires a surgery, during which Lana must be awake and talking so the doctors can gauge her brain function. Shaun and Morgan attempt to recruit Lana's roommate Javi, with whom she has a perfunctory sexual relationship. Javi, also autistic, overcomes his sensitivity to light to be present in the operating room, making the surgery a success; Javi admits his love for Lana. At the same time, Shaun struggles with Lea having a boyfriend. Shaun and Lea acknowledge they make each others' lives better; he agrees to give her needed privacy with Jake. Shaun's overbearing attempts to help an ill Glassman lead to a fight. Following Lea's advice, Shaun acts as a supportive friend rather than as a doctor, which Glassman appreciates.

A 14-year-old girl, Karin, is left brain dead following a car accident and Andrews asks Karin's mother Shannon to consent to a face transplant for Molly, whose face was destroyed by an accidental gunshot. Shannon consents only after Claire arranges for Shannon to encounter Molly. Melendez, Lim, Andrews, Morgan, Park and Claire perform a successful transplant. Melendez and Lim question their relationship, with Lim concerned that Melendez has uncharacteristically deferred to her, to the detriment of their initial treatment of Karin; they decide against breaking up. Shannon bonds with Molly and her parents; Shannon and Molly's father both blame themselves for the harm their daughters suffered. Shaun takes the day off to help Glassman, leading to the two getting high on Glassman's medical marijuana. As a result, Shaun, Glassman and an Uber driver undertake a successful quest to locate Robin, a woman Glassman was in love with in high school, so that he can apologize for an unkind comment he wrote in her yearbook. The experience causes Shaun to reexamine his own feelings for Lea and he admits to Glassman that he is "not all right" with Lea's relationship with her boyfriend Jake.

Glassman undergoes chemotherapy and rebuffs the social overtures of fellow patient Larry. He later embraces cancer as an identity and socializes with Larry and leukemia patient Candice. The hospital's new Chief of Surgery, Doctor Jackson Han, assigns Melendez to run tests on Minesh, a wealthy entrepreneur wanting a full workup. Melendez finds a leg tumor with a 95% chance of being benign; but if malignant, Minesh would soon die without risky surgery. Minesh decides to undergo surgery; the tumor is successfully removed, but Minesh will have a permanent limp. Minesh decides against learning the biopsy results; Melendez follows suit. Lim, Shaun, and Claire treat Persephone, a newborn with potentially fatal birth defects of the heart and bowel. Shaun tells Persephone's mother that her antidepressants may have caused the defects; Claire and Lim defend Shaun to an outraged Han. After a complex surgery is seemingly a failure, Shaun has a sudden inspiration that saves Persephone. Shaun's diagnostic skills impress Han, who transfers him to pathology - against Shaun's wishes - so he can save patients without interacting with them.

Glassman completes his chemotherapy and attempts to renew his relationship with Debbie. However, hurt by Glassman pushing her away while he was sick, Debbie rebuffs him. Melendez, Claire and Morgan treat Clarence, a pastor with spinal cancer who refuses a spinal fusion to fix his pain as Clarence blames himself for a parishioner's suicide and thinks he deserves the pain. After Clarence's cancer disappears without a medical explanation, Claire, who lost her faith at some point, convinces Clarence to have the spinal fusion. Lim and Park treat Sadie, a young woman who had a premonition that she would die and who appears to have an inoperable and aggressive brain tumor. Shaun, attempting to adjust to working in pathology, realizes that Sadie may have been misdiagnosed; he gets Han to retest her, proving Shaun's hypothesis that Sadie has a treatable parasite. Han publicly credits Shaun as the pathologist who saved a grateful Sadie's life. Shaun requests his old job back, but Han presents Shaun's unique ability to correctly diagnose Sadie as proof that Shaun belongs in pathology.

Han meets with the medical review board regarding the events of the quarantine and reaches a compromise where the hospital will pay some fines and Shaun, Lim and Melendez will have to attend a few classes, but are otherwise clear of trouble. Glassman's final test results shows that he is completely cancer free; after Glassman gives her a personal gift in thanks, Dr. Blaize suggests that his ordeal has changed Glassman for the better. Lim treats the newborn daughter of her old friend Laura who displays signs of shaken baby syndrome; Shaun determines that it was a birth complication, not abuse. Melendez assembles a large team to treat Kenny, a young man with a 200-pound tumor encircling his body. When complications arise, Melendez insists on bringing in Shaun to consult; Shaun is able to come up with a way to complete the operation safely, but continues to be excluded from the surgery. Thanks to Shaun, the surgery is a success. Shaun suffers an emotional breakdown and demands his job back from Han in a way that leads to Han firing him. After Laura accuses her of a lack of vulnerability and commitment, Lim decides to make her relationship with Melendez public and goes to Andrews with him.

Morgan and Park treat an elderly patient, Ida; Alex proves Ida is faking post-surgery symptoms, but he apologizes to her after Morgan researches Ida's sad, lonely life. Shaun skips a job interview to drink at a bar where his rambling causes another patron, Zack, to attack him; Zack then collapses. An embarrassed Shaun conceals the altercation; Carly, his old pathology colleague, discreetly helps him diagnose his own internal injuries. Shaun realizes that Zack has been misdiagnosed; Shaun collapses, seemingly saying "trampoline." With Shaun unconscious, Claire successfully replicates Shaun's thought process and diagnoses Zack with treponema, saving him. Shaun recovers. Andrews advocates for Shaun to an unmoved Han. At the risk of his own career, Andrews fires Han and rehires Shaun. Glassman proposes to Debbie; she declines, but later accepts. Claire coaches Shaun on how to ask a woman out, and tells him he will grow from his failures. Shaun asks Carly out; she says yes. Lim and Melendez make their relationship public, but Han's firing means one of them may become Chief of Surgery, necessitating a breakup. They agree neither of them should decline the position; Melendez reveals he already knows Andrews has chosen Lim; Aoki calls with the offer.

Morgan and Park diagnose elderly patient Harvey with kidney cancer and compete over who will lead the surgery, as new Chief of Surgery Lim will allow third-year residents to do so. Due to Harvey's dementia, the two come together to convince his wife to leave the cancer untreated, so that he can enjoy his remaining time. Melendez, Shaun and Claire treat a newlywed bride with extensive cancer. Shaun proposes a radical, high-risk surgery. With the support of her new husband, she successfully undergoes the surgery, but will permanently need an ileostomy bag; her husband affirms they will both learn its maintenance. Lim and Melendez officially break up, but the HR director deduces they will continue to date in secret, and tells them it will be difficult. With advice from Andrews, Lim learns to navigate her employees' requests and hires Andrews to replace her as attending surgeon. Shaun is convinced his eventful first date with Carly was a disaster, because the unpredictability of the experience overwhelmed him; despite his friends' advice, he decides another date is not worth it and avoids Carly. Glassman works at an underperforming clinic; Aoki convinces him to return as President by offering to reopen St. Bonaventure's clinic run by Glassman.

Morgan and Park continue to compete for who will perform the first surgery, but Lim chooses Claire. Lim and Melendez find themselves at odds over the treatment of a baby whose parents and evidence suggest that Melendez erred in a previous surgery; Melendez is ultimately exonerated and he and Lim save the baby together. Andrews, Shaun and Claire treat a Good Samaritan who had the side of his face destroyed while saving a total stranger. Andrews refuses to give up on the patient and saves his face with an experimental procedure devised by Shaun. Andrews subsequently recognizes that he was driven by anger over the repercussions for his own selfless act of saving Shaun, but realizes that it was worth it. Claire struggles with her mother moving in with her, eventually agreeing to let her stay with conditions. Shaun continues to struggle with his relationship with Carly; after receiving advice from his friends, Shaun decides to have a more relaxed and informal date with Carly in the pathology lab.

Morgan and Park treat Shamus, a man with a giant marlin impaled in his leg and who is more worried about the fish's safety than his own; the injury causes the doctors to discover that Shamus has cancer, requiring an amputation. Shaun develops doubts about his relationship with Carly after Claire points out that he asked many invasive questions for a new relationship; it turns out that Carly didn't mind Shaun's questions and orders Claire to butt out of their relationship. Claire treats Michelle, a teenager whose gallbladder removal is Claire's first surgery as lead doctor. Claire realizes that Michelle, who has a distant mother, is self-harming and her attempts to help upset the mother, which gets Claire kicked off the surgery. With Michelle and Melendez's support, Claire is allowed to perform the surgery, which is a success. Michelle's mother promises to seek psychological treatment for her daughter. Claire begins to bond with her mother, attending therapy together. However, Claire's mother later dies in a car accident after getting drunk on champagne Claire was saving to celebrate her first surgery.

Andrews, Park and Shaun treat Mitchell, a conspiracy theorist with a genetic liver disease and a belief that someone poisoned him; Shaun eventually realizes that Mitchell was inadvertently poisoning himself daily with herbs he's been taking for virility. Melendez, Claire and Morgan treat Lily, a woman who's unable to feel physical or emotional pain, resulting in a ruptured appendix and amputated hand. With her husband contemplating leaving her because he believes she cannot feel love without pain, Lily takes medication to gain the sensation of pain, but falls into a depression. Her husband promises to support her no matter what and she cries for joy before Melendez tells them he took Lily off the medication. Claire, still reeling from her mother's recent death, spreads her ashes with Morgan. Claire then has a drunken hookup with a stranger at a bar. Holding hands is important to Carly, but uncomfortable for Shaun; they find a compromise in crossing their wrists. Glassman has cold feet about marrying Debbie after realizing how little he actually knows about her, but after some advice from Shaun, Glassman and Debbie are married in a small civil ceremony.

Morgan and Claire treat Curtis, a man who comes in intoxicated despite supposedly being sober for over six years. Claire, who is still struggling with her mother's death, refuses to believe Curtis is telling the truth about his sobriety while Morgan searches for an alternative explanation; Curtis turns out to have a benign tumor that was causing his intoxication. At the same time, Glassman becomes uncomfortable after learning that Debbie carries a gun and attempts to dissuade her without success. Shaun receives his first lead surgery; his patient is Beth, a friendly woman with esophageal cancer and an apparently easy fix. Andrews realizes Lim is coddling Shaun which he warns against as Shaun struggles when the case becomes more complicated. During the surgery, Shaun finds a solution to the problem, but one too complicated for himself to perform; instead, Shaun guides Andrews and Lim through the successful procedure. Lim reminds Andrews that it was a team effort which is more important when he feels that Shaun failed as a surgeon for having to walk out. Shaun's relationship with Carly reaches a new level of intimacy after Carly let him touch her breast, much to Shaun's delight.

Shaun's first lead surgery is an appendectomy; though it is successful, Shaun kicks Nurse Hawks out of the OR for handing him a tool in a way other than his preference. Shaun's inability to apologize escalates the situation; Hawks files a formal complaint, and Lim threatens to fire Shaun if another such incident occurs. Melendez, Park and Morgan treat Patty, a twenty-three-weeks pregnant woman with an ovarian tumor. Lim & Melendez, and Patty & her husband, clash over her treatment as both Melendez and Patty want to save the baby, even at the risk of Patty's life. Patty dies in surgery, while her underdeveloped baby is delivered to an uncertain future; Melendez is devastated by Patty's loss. Debbie is fired from the coffee shop and convinces Glassman to hire her as his office manager. Carly has friends over and doesn't invite Shaun, leaving him doubting their relationship. Claire's meddling only exacerbates things, and Morgan confronts Claire over her increasingly self-destructive behavior, for which Morgan has been covering. Carly acknowledges that she was wrong to assume her friends would not accept Shaun. Carly refers to herself as Shaun's "girlfriend," and he is delighted that their relationship is official.

Melendez continues to struggle with the death of Patty resulting in him taking more caution with patients. After an intervention by Glassman, he tells Lim that he thinks they are both at fault due to their relationship removing objectivity from the decision to approve the surgery. Debbie's efforts to help in the clinic lead to an argument with Glassman. Andrews, Claire, and Morgan treat Charlie, a boy who is about to lose his sight due to cancer. Morgan and a reluctant Claire take Charlie on a fun day, leading to Claire connecting with him emotionally; fed up with Claire's continuing cynicism, a worried Morgan orders her to deal with her issues rather than let them change her. Shaun, Park and Melendez treat Tara, a young woman with no immune system. Park suggests using gene therapy to cure Tara's condition; Shaun's ability to empathize with Tara helps convince her to take the treatment. Tara is apparently cured and is able to emerge from her bubble and enjoy fresh air for the first time.

Melendez's continuing hesitation to take risks puts him at odds with Lim over the treatment of Wren, a young woman who plans to travel to the moon and thus needs both of her lungs intact; working together, Lim and Melendez successfully perform the surgery. Lim ends their relationship since she can't pursue her dream and be everything Melendez needs at the same time. Morgan is assigned her first lead surgery; Andrews reveals that he believes Morgan has it in her to be a leader. Privately, she reveals to Glassman that she has recently been diagnosed with rheumatoid arthritis and seeks his support for both treatment and help continuing her career; though Morgan is successful with the complicated surgery, her condition appears to be worse than she's willing to admit. Shaun and Park treat Rosalind, a doctor who advanced the field of leukemia treatment, but is in heart failure and has pushed everybody in her life away from her; Park convinces Rosalind's ex-husband Leo to be at her side as she dies. Shaun has trouble sharing intimacy with Carly, leading to troubles between the two; Park helps Shaun understand that much of his troubles come from fear and he commits himself to resolving the issue.

Claire's self-destructive behavior leads her into a moral dilemma when her latest one-night stand arrives in the hospital following a car accident and turns out to have a family; at Claire's urging, his wife forces him to tell her the truth, leading to Claire getting publicly slapped. Morgan, Shaun and Andrews treat Jeanie, a young woman who refuses to have life-threatening tumors removed because it would also remove her ability to have sex; Morgan convinces Jeanie's fiancé to get her to have the surgery. Lim and Melendez's relationship remains strained following their breakup; Lim eventually admits to having second thoughts about the breakup. Shaun tries to have sex with Carly for the first time, but has trouble with the intimacy and vulnerability; before leaving, Shaun admits that his greatest fear is that Carly will tire of his issues and leave him. At the end of the episode, Glassman brings Shaun the news that Shaun's father has pancreatic cancer and may only have a few days left to live.

Claire, Melendez, Park and Morgan treat Art Kalman, a professional football player who broke his back at the gym. Morgan's suggested course of treatment proves effective and he is expected to be able to return to football but Art reveals that he hates the sport and felt pushed into it, purposefully injuring himself as a way of getting out. After Art explains he feels obligated to his family, particularly his mother, Claire uses her own experiences to convince him to be honest with his family and quit. Claire, who is shown to be communicating with a possible new boyfriend, finally starts seeing a therapist for her own issues. At the same time, Shaun returns to Wyoming with Glassman and Lea to see his dying father Ethan. After exploding at the man, Shaun is convinced by his friends and mother to make peace with Ethan. In return, Ethan proves only to have venomous words for Shaun before passing away. A distraught Shaun allows Lea to hold him as he breaks down in the aftermath.

Park and Claire treat Luca Jones, a man who became a drug mule after falling on hard times; Claire clashes with Park over whether or not to turn Luca into the police, sympathetic with his circumstances. Luca later flees the hospital with drugs that were surgically removed from him, suggesting that Park was right about him. Claire continues seeing a therapist who suggests that she has PTSD. Shaun and Morgan treat Kerry, a patient with a badly broken leg who refuses painkillers or anesthesia due to being an opioid addict; after she continues to refuse despite her husband's reassurances that he will stand by Kerry, the team is ultimately forced to perform a very painful operation on her, which she endures while conscious and sensate. After spending the night with Lea, Shaun struggles with his feelings for Lea and Carly. Glassman comforts him through a brief emotional breakdown over his fears of ending up alone. Shaun tells Carly the truth and she asks for some time alone. She later thanks Shaun for his honesty, and asks him to stop living with Lea if Carly and Shaun's relationship is to progress; Shaun agrees and tells Carly that he loves her.

Shaun, Morgan, Andrews, and Lim treat James, a man who is suffering swelling due to a genetic mutation which makes his treatment extremely difficult; if not properly treated, he will drown in his own fluids. As a result, Carly is called in to help the team, but she struggles with dealing with a live patient rather than samples; Carly and Shaun's research using zebra fish ultimately finds a treatment that saves James' life. At the same time, Claire, Park, and Melendez treat Angie, a cancer patient whose brain tumor has returned and whose mother tries to keep her boyfriend Ryan (a cancer patient himself whose tumor has just been discovered gone) away from her; at Claire's suggestion, the hospital throws the teens a small prom. However, the tumor proves impossible to remove even with Glassman's help and Angie dies shortly afterwards; Ryan and her mother find comfort in each other in the aftermath. Morgan is suffering from nausea due to the medication for her rheumatoid arthritis while Claire continues to struggle with her mother's death; Melendez offers comfort via jogging. Shaun and Carly continue to struggle following their fight; after saving James, they have sex for the first time.

The team treats Caroline Reznik, an artist who needs a lobectomy to treat her cerebral cavernous malformations; Caroline turns out to be Morgan's long-estranged mother and it is revealed that she is from a family of famous artists. Morgan eventually finds another solution that she and her brother Ariel get Caroline to accept; after some convincing, Glassman successfully performs the surgery. At the same time, Shaun and Melendez treat Oliver, a man dying of cancer who is determined to live life to the fullest while putting himself at great risk; this leads to his wife leaving him due to feeling like Oliver is not putting her first. Morgan induces a seizure on her artist mom after finding out about what has been going on with her. Oliver develops an infection that ironically saves his life by causing his own immune system to attack and shrink the tumor to the point that it can be removed; afterwards, Oliver appears to be left directionless. After learning that Carly was unsatisfied by the sex they had, Shaun studies sex to be better the next time; by comparing Shaun's focus on sex to his focus on surgery, Lim is able to give Shaun helpful advice that finally allows him to pleasure Carly.

Claire, Park, and Melendez treat Ann, a mother who fell ill after trying a home remedy she found on the Internet for her urinary tract infections. Ann's diagnosis helps discover serious heart ailments in her three-year old daughter Marla. Marla soon has a heart attack, but the doctors successfully treat her and promise Ann that, with lifelong medication, Marla would enjoy a long and healthy life. Meanwhile, Shaun, Morgan, and Andrews treat Kayley, a social media influencer. During Kayley's surgery, a complication arises when Morgan slips; though quickly corrected, both Glassman and Morgan are left concerned that it was due to her rheumatoid arthritis. Kayley draws media attention to Shaun for saving her life that leaves him uncomfortable. After consideration, Shaun refuses, wanting to be known as a good doctor, not a good autistic doctor. At the same time, his continuing friendship with Lea causes friction with Carly. Carly admits she's jealous of Lea and decides to work on it. After Lea quits her job, Shaun convinces a reluctant Glassman to hire her as his assistant. Both Park and Morgan notice the growing closeness between Claire and Melendez. Shortly, an anonymous favoritism complaint towards Claire is filed against Melendez.

Lim, Morgan, and Shaun treat Cory, a young boy born without a fully-developed trachea or a larynx; after an experimental surgery to give him a trachea, Shaun comes up with a way to give Cory a larynx. Morgan is revealed to have been the one to file a complaint against Melendez and she shows increasing signs of deterioration from her rheumatoid arthritis. At the same time, Melendez, Park and Claire treat Fran, a firefighter who suffered a serious arm injury in a dog attack. Tensions rise between Park and Claire after Park takes credit for the complaint against Melendez, which causes a strain in Melendez and Claire's friendship; after being confronted about his behavior by both Lim and Claire, Melendez begins repairing his friendship with Claire. Though Carly appears to be okay with Shaun's relationship with Lea, after a charged night of karaoke with Lea and her current boyfriend, a heartbroken Carly breaks up with Shaun, insisting that he and Lea love each other and Shaun should be with her.

An elderly Jane Doe comes into the ER with an aneurysm and dies on the operating table. Shaun becomes convinced that there is more to Jane's death and works to find Jane's family. He and Park locate her son Jules. Shaun learns that the Jane Doe, Maribel, had a rare deadly condition that Jules inherited. At the same time, Morgan, Andrews, and Claire treat Aiden Porter, a young man who injured himself and subsequently displays blackouts and sleepwalking during which time Aiden has a completely opposing personality. Aiden is discovered to have a cyst on his hypothalamus causing his condition but he resists having it drained and getting rid of his alternate personality. Morgan convinces the second personality to agree to the treatment. She also confesses and apologizes to Claire for making the favouritism complaint. Lim finds herself drawn to a young girl she spots wandering around the hospital who turns out to be an abandoned baby Lim found eight years before. She helps her get through her fears. Shaun confesses his love for Lea, but she refuses to be his girlfriend as she fears that dating her will be too much for Shaun to handle.

Shaun, Melendez, and Claire treat Alice Gottfried, who has a rare condition that requires her adrenal glands to be removed. With Alice refusing the treatment, Shaun invents a better surgery that is successful and which Melendez allows Shaun to perform himself. At the same time, Andrews, Morgan, and Park treat Wes Keeler, a survival instructor for at-risk youth who has developed a serious infection from a cactus prick, requiring a kidney transplant. One of his mentees, Max, proves to be a match, but Lim refuses as she feels Max isn't mature enough to make the decision despite Andrews, Morgan, and Park being on Max's side. At Wes' request, Lim lies to Max about the results, but Wes is left with little time to live unless they can find a suitable donor. Park's son Kellan visits, leaving Park worried at his panic attacks and withdrawn state. Claire's old friend Dash returns to visit and asks Claire on a date which she appears to accept on Melendez's advice. Lea once again rejects Shaun, but this time she specifies that it's because of his autism, which is something he can't "fix", leaving Shaun devastated.

Shaun, reeling from Lea's double rejection, returns after three days at home and works with Claire and Melendez to treat Finn, a patient with a breathing disorder and two girlfriends; one learns of the other and vandalizes Finn's car. Shaun gets drunk and plans to vandalize Lea's car, but she catches him in the act and Shaun instead shouts at her about her negative feelings towards his autism. Park, Morgan, Lim, and Andrews treat a farmer who has pain and limited strength after having had both arms reattached after an accident. Andrews recommends amputation, which Lim doesn't want to do, but ultimately has to. Morgan reveals her rheumatoid arthritis to Lim and says the surgery will be her last, but changes her mind after the farmer's successful operation. Despite Glassman's disapproval, Morgan decides on a synovectomy to prolong her surgical career at the risk of permanent disability later in life. Claire admits to Melendez that she doesn't want a relationship with Dash and he tells her she makes him a better person. Claire later tells her therapist that she loves Melendez.

Melendez, Glassman, and Lea are attending a charity fundraiser at a brewery for Marta, one of Melendez's former patients. Marta's wife, Noreen, gives them a tour of the brewery when a massive earthquake hits, trapping Lea in the basement and injuring Melendez on the head. Lim organizes assistance at the brewery while Andrews oversees E.R., but Morgan takes charge when Andrews starts operating with Glassman. Shaun looks for Lea while Park and Lim treat Casey, a young man trapped under a beam. Park proposes a very risky surgery to save Casey's life. Melendez and Claire have to operate on Marta in-situ to save her from certain paralysis. Meanwhile, Shaun finds Vera in the basement; her leg is impaled on steel cords which he can't remove. They bond as Shaun admits he doesn't want to move on from Lea (who has been rescued and is listening on a two-way radio). Just as Melendez and Claire get Marta to an ambulance, an aftershock hits; Melendez collapses from his injuries and the basement begins to flood. At the hospital, Morgan, despite her synovectomy, decides to operate on a young woman with an ectopic pregnancy with only a nurse to assist.

Lim and Park's surgery on Casey fails; Park remains with Casey who reveals that he blames himself for his mother's death and wants to make amends with his father for his perceived mistake. With Casey's father unable to make it in time, Park pretends to be him to give the young man peace before he dies; the experience causes Park to decide to move back to Phoenix to be closer to his family. Lim returns to the ER where Claire calls her in to help treat Melendez who has internal bleeding; while performing surgery to repair it, Claire and Lim discover damage to Melendez's bowel that can't be repaired. Melendez makes peace with Lim and he and Claire express their feelings for each other before Melendez dies; Lim and Claire comfort each other in the aftermath. Morgan succeeds in saving her patient, but Andrews warns that the damage she did to her hands in the process might have destroyed her surgical career forever. In danger of drowning with Vera, Shaun is forced to perform a leg amputation in just a few minutes while a helpless Lea listens over the radio. Shaun succeeds in saving Vera and starts a relationship with Lea who realizes how much she loves Shaun after nearly losing him.